Can Serum Prolactin Be a Reliable Marker for Preeclampsia? a Hospital Based Study on Nepalese Mothers
نویسندگان
چکیده
Preeclampsia is a pregnancy specific complication characterized by hypertension, proteinuria and oedema. It has remained as a major cause of maternal and perinatal morbidity and mortality worldwide. The major function of prolactin is its role in lactation during pregnancy, but many authors have claimed that this hormone is also involved in angiogenesis, thus linking it with the pathogenesis of preeclampsia. In this context, our study aims to compare the serum prolactin level between preeclamptic and healthy pregnancies and correlate with the severity.A total of 54 pregnant women diagnosed with preeclampsia and 60 age and gestational weeks matched healthy pregnant women were recruited in this case control study. Preeclampsia was defined as per Australasian Society Consensus Statement research definition. Among 54 preeclamptic women, 41 had mild preeclampsia and 13 had severe preeclampsia. The mean age and the gestational weeks of the preeclamptic cases and pregnant controls were not significantly different. This study showed that the median concentration of prolactin was significantly higher in preeclampsia than in normal pregnancies (156.6 vs. 129.8 ng/mL, P=0.012). Though the median concentration of prolactin was higher in severe preeclampsia in comparison to mild one, the difference did not reach the significant level (228.3 vs.152.9 ng/mL, P=0.061). No significant correlation of prolactin was found with mean arterial pressure and 24h UTP. Due to poor correlation with established markers of severity, serum prolactin is not a reliable marker of preeclampsia.
منابع مشابه
The Effect of Metoclopramide on Prolactin Levels in Breastfeeding Mothers: A Systematic Review and Meta-Analysis
Background: Exclusive breastfeeding is beneficial to not only infants, but also mothers. Since prolactin stimulates milk production, increasing its levels through dopamine antagonists, such as metoclopramide, may enhance milk production. However, the efficacy of this method should be further studied. Therefore, this systematic review sought to determine the effects of metoclopramide on prolacti...
متن کاملComparison of the Serum Level of Carcinoembryonic antigen, Prolactin, and Malondialdehyde in Patients Suffering from Breast Cancer and in Healthy individuals in Isfahan
Background & Objective: One of the most prevalent types of cancer among women is breast cancer. The objective of this study is to compare the serum level of tumor marker of Carcinoembryonic Antigen (CEA), Prolactin, and oxidative marker Malondialdehyde (MDA) in patients with breast cancer and in control groups. Materials & Methods: This case control study was carried out on the people wh...
متن کاملEVALUATION OF FREQUENCY OF MATERNAL AND FETAL COMPLICATIONS IN PATIENTS WITH PREECLAMPSIA ADMITTED TO MOTAHHARI HOSPITAL IN URMIA IN 2019
Background & Aims: Preeclampsia is one of the most serious complications of pregnancy. Preeclampsia can lead to dysfunction of various organs such as the liver, kidneys, and brain, leading to maternal and fetal complications. In this study, we intended to examine the various complications that occur in the mother and fetus due to preeclampsia. Materials & Methods: In the present study, the res...
متن کاملSerum prolactin level in psoriasis
The recent report, “Serum prolactin level in psoriasis”, is very interesting 1. Ghiasi et al. concluded that “it seems that while intracutaneous prolactin may contribute to the pathogenesis of psoriasis, the probable role of pituitary-produced circulating prolactin in the disease process needs further investigation .” There are some concerns on this report. First, although Ghiasi et al. have st...
متن کاملComparison the Effect of Foeniculum Vulgare Miller (Fennel) on Serum Prolactin and Weight Gain with the Effect of Domperidone and Placebo in Yasuj city in 2018
Breastfeeding is an economic and valuable method to protect infant health during the life and provides unique biological and emotional effect for mothers and infants. Objectives: This study was designed to compare effect of fennel on maternal serum prolactin level and neonatal weight gain to effect of domperidone and placebo on these variables. Research method and materials: In this study 1...
متن کامل